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Thus the GSH/GSSG ratio is important to normal functioning and is a likely contributor to cellular signaling pathways by activating or inactivating key thiol-containing enzymes

The iron-overload state commonly observed in AD brains exacerbates neuronal oxidative damage and, through the release of pro-inflammatory mediators and activation of immune cells, contributes to the structural disruption of the BBB

61 In a rat model of IC/BPS, injecting adipose tissue-derived mesenchymal stem cells into the bladder wall reduced the number of mast cells, collagen activation leading to fibrosis, hypersensitivity to pain, and over-activity of bladder musculature

Improved cellular energy production may indirectly support the processes that maintain antioxidant balance

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