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6), we propose that treatment with 1.325nM of Rot in primary cortical neurons induces CI inhibition, leading to reduced ETC activity, diminished mitochondrial respiration, and consequent decreases in ATP levels and superoxide production

Cell 135: 933947 MeseckeN,TerziyskaN,KozanyC,BaumannF,NeupertW,HellK,HerrmannJM (2005) A disulfide relay system in the intermembrane space of mitochondria that mediates protein import

Its primary job is to facilitate energy metabolism