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6,7 Conversely, nonsurgical periodontal therapy such as scaling and root planing have demonstrated an increase in glutathione levels, suggestive of an improved antioxidant status and reduction in oxidative stress, perhaps partly due to a reduction in the proteolytic activity of bacteria and reductions in inflammation

This can confirm a mast cell disease diagnosis

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Effects of creams containing vitamin C, a copper-binding peptide cream and melatonin compared with tretinoin on the ultrastructure of normal skinA pilot clinical, histologic, and ultrastructural study

However, these observations are limited by methodological shortcomings, and the strength of the association appears weak