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NET-containing guanylated peptides can be internalized by FLSs through the TLR9 pathway, elevating the inflammatory phenotype of FLSs and upregulating the expression of major histocompatibility complex class II molecules, which subsequently produce autoantibodies by presentation to Ag-specific T-cells (168)

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Description 5-Amino-1MQ is positioned in research contexts as an NNMT (nicotinamide N-methyltransferase) pathway small molecule, not an NMN (nicotinamide mononucleotide) profile, with interpretation generally anchored to broader NNMT inhibition literature

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