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The concentration of nitric oxide (NO) was only significantly lowered for the rabbits supplemented with a higher concentration of YSE before injection, but after the procedure, there was no significant decrease in the upraised level of plasma NO

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Pulmonary vascular remodeling(PVR) is the crucial pathological hallmark for increase of pulmonary arterial pressure, and critical for PH treatment[5]

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Thus, future studies should include other inflammation-related biomarkers which may explain part of the variance in the clinical neuropsychiatric symptoms, including autoimune responses, the cytokine network, the NLRP3 inflammasome, and hypernitrosylation