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Azzam EI, Jay-Gerin J-P, Pain D (2012) Ionizing radiation-induced metabolic oxidative stress and prolonged cell injury

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ClinicalTrials.gov - PCO-02 - Safety and Pharmacokinetics Trial (NCT02637284): Specific details of the Phase 1 trial

The experiment demonstrates the potential of IGF-I treatment of catabolic states and especially the value of modified forms of growth factors that bind weakly to IGF-binding proteins. In another study in the Journal of Developmental Cell , IGF-1 LR3 was shown to help prevent muscle wasting and stimulate muscle growth through the activation of the IGF1R/IRS1/PI3K/Akt pathway

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