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4d, where it alleviated hyperactivity at low dose, but worsened such behavioral abnormality at a higher dose

Furthermore, these molecules also have extrapancreatic mechanisms of action that contribute to their glucose lowering properties, such as slow gastric emptying and increase satiety (Figure 1)

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An RCT in patients with overweight or obesity found that a 12-week hypocaloric TRE regimen led to a greater loss of lean mass compared to a conventional hypocaloric diet ( 3.3 Chrononutrition Circadian misalignment in food intake may also impact metabolic and cardiac health ( CLOCK has been associated with differences in glucose tolerance and lipid metabolism ( Similar to breakfast skipping, late-night eating has been linked to arterial stiffness ( Chrononutrition is an important modulator of peripheral clocks in the circadian system controlling blood pressure rhythms ( versus breakfast) require further investigations through controlled studies to elucidate how meal timing impacts HPA axis rhythmicity and cardiovascular risk factors, including fluctuations in blood pressure and glucose levels