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"From a dermatology standpoint, the biggest concern is the effect on moles," Goldinger said

A patient on 2.4 mg of semaglutide weekly might reduce to 1.0 mg or even 0.5 mg for maintenance

To summarize several meta-analyses of CVOTs conducted with GLP-1RAs, it isconfirmed that based on 43 trials, GLP-1RAs are a class of efficacious agent for reducing MACE (MH-OR 0.87 [0.83, 0.92]), cardiovascular and all-cause mortality (MH-OR 0.89 [0.83, 0.96]) [48]

[DOI] [PubMed] [Google Scholar] 47.Geerling JC, Shin JW, Chimenti PC, Loewy AD