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Since, both human (153, 155) and murine (163, 164) LN metastases can seed distant metastases, the abundance of heterogeneous cancer cell subclones in LNs could potentially give rise to more treatment-resistant cancer cells, such as the ferroptosis-resistant clones (62) or immune-resistant clones (57, 59), which spread systemically and generate secondary metastases

Primers used for RT-qPCR are listed in Table S1