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Some studies have demonstrated the ability of gut-derived GLP-1 to cross through the blood-brain barrier and thoroughly perfuse the brain parenchyma, but whether its effects are similar to that of PPG-derived GLP-1 remains to be established [50, 53]

The primary objective was to evaluate the models ability to produce accurate probability estimates using Minimal Significant Difference (MSD) as a test case by analyzing patient-specific variablesincluding demographics, baseline patient-reported outcome (PRO) scores, Patient Global Impression of Change (PGIC) as the anchor, clinical measurements, and treatment history

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