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What they found (summary): Development of Melanotan II as a cutaneous drug failed due to the combination of side effects Bifurcation into more selective derivatives was both scientifically and commercially successful PT-141 Bremelanotide (Vyleesi, 2019) Melanotan I Afamelanotide (Scenesse, 2014) Underground use of Melanotan II is safety-problematic Why it matters: This is the definitive historical review by the founders of the field

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Am J Respir Crit Care Med 171 : 431439 Fitzpatrick AM, Brown LA, Holguin F, Teague WG, National Institutes of Health/National Heart, Lung, and Blood Institute Severe Asthma Research Program 2009 Levels of nitric oxide oxidation products are increased in the epithelial lining fluid of children with persistent asthma

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