In addition to their role in promoting breast cancer cell proliferation [67] and mediating inflammation [68], breast CAFs deposit collagen type I and fibronectin [58], secrete matrix metalloproteinases (MMPs) [69], and promote collagen crosslinking (e.g., via lysyl oxidase (LOX)) [70]
Modulation of nitric oxide (NO) pathways via the AkteNOS axis, improving blood flow, normalizing coagulation, and protecting vascular endothelium, including prevention and reversal of thrombosis in some animal models
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Molecular mechanisms of the acute kidney injury to chronic kidney disease transition: an updated view
Improves mood and behavior