While ertugliflozin did not outperform placebo for MACE, it significantly reduced hospitalizations for HF by 30% ( The SCORED clinical study, which included 10,584 patients with T2DM and an estimated glomerular filtration rate (eGFR) of 2560 ml/m/1.73 m, evaluated the effects of sotagliflozin on cardiovascular death and hospitalization for HF
Reddy's did not disclose pricing details except to say that it will be competitive [Source: globalnews.ca/news/11857122/generic-semaglutide-canada-sales-begin/]
[DOI] [PubMed] [Google Scholar] 138.Fultang J, Chinaka U, Rankin J, Bakhshi A, Ali A Preoperative bariatric surgery predictors of type 2 diabetes remission
Importantly, GLP-1RAs do not exert direct immunosuppressive effects but instead modulate inflammatory pathways indirectly through metabolic and cellular mechanisms, supporting a favourable safety profile when used alongside bDMARDs
Drospirenone: pharmacology and pharmacokinetics of a unique progestogen
