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Current evidence suggests these medications lead predominantly to fat loss, but some lean mass loss may occur during weight reduction, particularly if patients are eating too little overall or not consuming enough protein

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Participants in studies often experience: Weight loss ranging from 10% to over 20% of their body weight within a few months Reduced appetite and fewer cravings Improved markers of metabolic health such as lower triglycerides and better cholesterol profiles One study published in a reputable medical journal reported that patients using retatrutide lost an average of 15% of their body weight over 24 weeks