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If an adverse reaction does occur, discontinue the infusion, evaluate the patient, institute appropriate countermeasures, and if possible, retrieve and save the remainder of the unused vehicle for examination

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Reduced uridine diphosphate-glucuronosyltransferase activity decreases bilirubin conjugation, leading to intrahepatic cholestasis and unconjugated hyperbilirubinemia

Stress, Cortisol, and Oxidative Burden Chronic psychological stress elevates cortisol and other stress hormones, which increase oxidative stress through multiple mechanisms including promotion of inflammatory cytokine production, impairment of antioxidant enzyme function, increased metabolic rate and oxygen consumption, and disruption of sleep and other restorative processes

Clinical Update 2/13/2024 PEA for Migraine