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ZIP13 dysregulation has further been implicated in myocardial ischemiareperfusion injury and broader connective-tissue pathologies 63,143

While NAION can happen spontaneously in people with risk factors such as diabetes, hypertension, and sleep apnea, researchers began to wonder if GLP-1 medications might increase risk

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By targeting glycemia, weight, and BP simultaneously, GLP-1 RAs offer a pleiotropic benefit that distinguishes them from traditional antihypertensive drugs and positions them as valuable adjuncts in comprehensive risk reduction strategies