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In this case I stop, change needles and choose another site

Chan JC, Cockram CS, Critchley JA

The single published human case series and unpublished clinical trial data provide preliminary safety reassurance but insufficient evidence for clinical efficacy claims

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In the absence of coenzyme B 12 , tetrahydrofolate cannot be regenerated from its inactive storage form, 5- methyltetrahydrofolate, and a functional folate deficiency occurs