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Use of SSRIs in Psychiatric Disorders In the pathology of various mood disorders, serotonin is widely implicated [80]

A slowed metabolism and weight gain can occur for a variety of reasons, such as not eating enough calories, too much cortisol, high insulin levels, or thyroid problems

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In contrast to EAE where the primary stimulus is immune upregulation in the presence of extrinsic myelin antigens, the CAE model illustrates that MS-like pathology can also be generated by an upstream intrinsic myelin injury, releasing antigens which secondarily trigger white matter inflammation in an immune-predisposed host