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GI side effects common during titration

DOSE RATE Lambs 0.5 mL at tailing or weaning Sheep 1 mL pre-lambing Calves 2-3 mL from 2 months of age Cows 46 mL pre-calving Injection into the anterior half of the neck in food producing animals

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And the clinical results have improved with each step up in receptor complexity

In vivo characterization of functional states of cortical microglia during peripheral inflammation