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Liraglutide, a GLP-1 receptor agonist (GLP-1RA), was shown to reduce serum total cholesterol, LDL-C, high-density lipoprotein cholesterol (HDL-C), and TG levels by decreasing hepatic LDLR and PCSK9 expression in db/db mice, but not in wild-type mice [16]

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(135) demonstrated that metformin mixed with sorafenib promoted iron apoptosis via the p62-Keap1-Nrf2/HO1 signaling pathway, inhibiting the value-added of HCC cells