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A recent review summarizes safety gaps and the regulatory context in the FDA context

Crucial NITs in NAFLD patients stratification are especially the fibrosis-4 (FIB-4) - an index that takes into account age, transaminases and platelet count- and the liver stiffness evaluation by VCTE

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As GPX4 serves as the master regulator of lipid hydroperoxide reduction, its suppression triggers irreversible lipid peroxide accumulation that culminates in ferroptotic cell death (67, 68)

Slices were evaluated by an experienced pathologist in a blinded manner, and histological scores were assessed based on the following parameters according to previous research: inflammation, epithelial defects, crypt atrophy, dysplasia/neoplasia, and the area affected by dysplasia 9