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For the remaining patients, particularly those who are overweight or normal weight, management must address the full spectrum of pathophysiological endotypes: craniofacial anatomy, muscle responsiveness, arousal threshold, and loop gain, says Gottlieb, head of applied science at Sleep.ai

Newer ERAs have since been designed that preferentially target endothelin A receptors, associated with inflammation and podocytopathy, over endothelin B receptors, associated with vasodilation and natriuresis [74]

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