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Often silent until you notice: Frothy/foamy urine (like soapsuds) that doesnt dissipate Swelling in ankles, feet, or face (edema) Unexplained fatigue or shortness of breath Elevated blood pressure These warrant prompt ACR testing not waiting for blood work

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Someone carrying high-risk variants in these pathways may experience faster appetite return and stronger cravings once medication ends compared to individuals with protective genetic profiles