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Your provider may reduce your dose, suggest a longer timeline before increasing your dose, or recommend other ways to manage these side effects
Suskind, and Christopher J
Discussion It is well acknowledged that high dose and long term use of NSAIDs are associated with adverse effects that include cardiac, gastrointestinal, renal and hepatotoxicity 32,33
All these effects can partly be explained through the impact of OS, caused by the inequality between ROS production and antioxidant defense mechanisms (Figure 5) (153)
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