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(ii) In human studies, this includes differences in race and patient age, as well as sex, diet, and drug use, which can cause changes in the composition of the gut bacterial microbiota and alter the relationship between plasma TMAO levels and atherosclerosis

doi: 10.1089/thy.2013.0676

No other single-agent weight loss peptide has posted numbers like that in a randomized controlled trial

Weight loss as cardiovascular medicine Retatrutide produces the most dramatic weight loss of any peptide studied to date, with mean reductions of 24 to 26% body weight at the highest doses