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Month 4-6: Reassess both therapies

Key sources of advice include: Your dispensing pharmacist community and hospital pharmacists are trained in medicines storage and can advise on what to do if storage conditions have been compromised Your GP or prescribing clinician particularly important if you are receiving retatrutide through a clinical trial or named-patient supply The clinical trial coordinator or sponsor if you are a trial participant, the trial team should be your first point of contact for any medicine-related concerns, including storage queries and cold-chain breaches NHS 111 available 24 hours a day for urgent medicines advice when your usual healthcare team is unavailable The Specialist Pharmacy Service (SPS) provides authoritative UK guidance on medicines requiring refrigeration, maintaining the cold chain, and handling storage breaches

Adjusting dose based on response Initial dosing represents a starting point, not a final destination

But it does not directly address the diseased tissue at the core of lipedema

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