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For any compound that will be used for decades in chronic disease, a dedicated MACE (major adverse cardiovascular events) trial is required

Bariatric surgery and suicide risk in patients with obesity

Exogenous administration of amylin consistently reduced food intake and body weight, 18-21 whereas amylin-knockout mice exhibited increased adiposity and impaired glycemic regulation, confirming its role in appetite and energy balance

To answer this, head-to-head studies comparing oral semaglutide and subcutaneous liraglutide or semaglutide have been conducted

Moroni F, Di Paolo ML, Rigo A, Cipriano C, Giacconi R, Recchioni R, et al