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One small study suggests it may not, but further research is needed before being able to make recommendations based on the information

While GLP-1 medications have a low intrinsic risk of hypoglycaemia when used alone, this risk increases when combined with insulin or sulfonylureas, which may require dose adjustment of these other medications

doi: 10.1002/iub.2031

Future Directions and Research Priorities Emerging Therapeutic Approaches Triple agonist retatrutide and combinations including cagrisema have progressed to phase 3 trials as obesity treatments with early data suggesting even greater weight loss than tirzepatide [83]

The study also found that weight regain after stopping medication happened much faster than after weight loss achieved through diet and physical activity