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Metformin in Non-Alcoholic Steatohepatitis

Journal of the American Medical Association 285, 11781182

The condition is most common in those over age 40 and athletes

Our results are also consistent with publications showing that CAV-1 reduction upregulates angiogenesis-related factors as evidenced by an inverse correlation between CAV-1 and VEGF in osteosarcoma 28 , increased CXCR12 expression in CAV-1 silenced fibroblast 29 , and a significant negative correlation between osteopontin and caveolin-1 levels in human osteoarthritic cartilage 30

Dimethyl sulfoxide (DMSO, vehicle) (#D2650), Vincristine Sulfate (Vin) (#V8388), N-acetyl-cysteine (#A15409) and retinoic acid (#R2625) were from Merck