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If you are low in energy or mood, catch everything going or suffer from digestive disorders, you could benefit from taking a daily B complex or Vitamin B12 supplement

Ofer Reizes, PhD: That was five years ago that we published that original paper

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However, the effect of oral vitamin B 12 varies among patients (13), and the available randomized controlled trials comparing the two treatment regimens are considered to be of low quality (14)

One animal study (Valdecantos et al., ADA 2024) showed obese rats given both compounds at sub-maximal doses lost more weight than either compound alone