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Mitochondrial signalling: MOTS-c is the only compound in the group targeting the AMPK/SIRT3 axis, addressing the metabolic driver of epithelial dysfunction

In addition to its potential influence on sleep patterns, DSIP appears to influence levels of corticotropin, inhibit the production of somatostatin, reduce stress hormone secretion, maintain normal blood pressure, alter sleep patterns and also may impact pain perception

Finally, investigating butyrate combination therapy strategies (e.g., with anti-inflammatory drugs or ferroptosis inhibitors) and joint-targeted delivery systems (e.g., nanocarriers) to enhance its local bioavailability will be crucial

A standardised saffron extract improves subjective and objective sleep quality in healthy older adults with sleep complaints: results from the gut-sleep-brain axis randomised, double-blind, placebo-controlled pilot study

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