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The IGF-1 pathway will lead to further oxidative stress

Dormancy is further stabilized by intrinsic regulators such as lncRNA NR2F1-AS1, which regulates stemness to prevent metastatic activation, and laminin-211 from the astrocytes in the brain, which maintains quiescence through dystroglycan signaling (163)

In particular, long-term use of non-steroidal anti-inflammatory drugs (NSAIDs) can cause gastric mucosal damage as they can inhibit mitochondrially encoded cytochrome C oxidase I (MT-CO1, also known as COX-1) and block its protective effect on gastric mucosa

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Be sure to use sunscreen during the day for best results