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Overall, the therapy of metformin was associated with changes in the abundance of specific bacterial genera in the human gut microbiota, but the effects on gut microbiota diversity were variable, which highlights the need for further research to understand the potential mechanisms and clinical significance

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[186] Appetite suppression and reduced energy intake further contribute, with phase 2 data showing decreased hunger, food cravings, and preference for high-fat foods, leading to caloric deficits without compensatory increases in resting energy expenditure

The Aspirin Regimens in Essential Thrombocythemia (ARES) phase II randomized trial design: Implementation of the serum thromboxane B2 assay as an evaluation tool of different aspirin dosing regimens in the clinical setting