Microneedling, creating tiny accidents within the skin, may additionally irritate this sensitivity and cause redness, irritation, and aches
The biological roles proposed for GHK-Cu in the research literature have included effects on collagen and extracellular matrix synthesis (through copper-dependent enzymes including lysyl oxidase), on antioxidant gene networks (where copper participates in both prooxidant and antioxidant chemistry depending on context), on growth factor activity in tissue repair, on hair follicle biology, and on broader transcriptional programs characterized in microarray and RNA-seq studies
doi:10.1515/9783111510828-118
But the leap from animal models to human outcomes is large
signaling, r., Utilization of the insulin-signaling network in the metabolic actions of alpha-lipoic acid-reduction or oxidation