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Research indicates that weight loss triggers neurohormonal responses designed to defend against further weight reduction, creating a biological drive to eat that may override medication effects in susceptible individuals
When it first appeared, the drug won a nod to prescribe for obese patients with an initial body mass index of 30kg/ or more or overweight adult patients with a BMI from 27kg/ to 30kg/ having one or more weight-related comorbidities
Reconstituted material should be stored at 28C, protected from light, and used within 30 days
Compounded tirzepatide is a dual GIP and GLP-1 receptor agonist, a once-weekly injection that activates two distinct metabolic pathways simultaneously
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