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Semaglutide is an FDA-approved GLP-1 receptor agonist with well-characterized benefits and side effects through large phase 3 obesity and diabetes trials

They said the agency has no authority to require compounders to submit safety or efficacy data once a substance is added to the list

The IDEA trial protocol used diet plus exercise for weight loss in knee OA and showed dose response

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This finding has implications for functional GI disorders, though it remains preclinical 10