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Gastrointestinal side effects like nausea and diarrhea are much more common

In the context of T2D, the ability of GIP to stimulate insulin secretion and to ameliorate glycaemia is impaired [35]

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While some telehealth companies have completely ceased offering tirzepatide and semaglutide, others have adjusted their offerings so that they are either in oral formats (like dissolving tablets) that are different than injectables, in custom dosages, or sold with additives like vitamin B

Liraglutide and dulaglutide generally show better tolerability but still require careful counseling to maintain adherence ( Overall, the comparative evidence suggests that long-acting and multi-agonist agents maximize efficacy at the expense of higher gastrointestinal intolerance, whereas older agents provide more modest benefits with relatively favorable tolerability