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(61) demonstrated that combined L-carnitine and nicotinamide riboside administration upregulated multiple metabolic and insulin signaling regulators ( Ppargc1b, Acox1 ), promoting mitochondrial oxidative phosphorylation and peripheral glucose uptake

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The SP-2509 lytic suppression effect was recapitulated with another target cell, the acute leukemia line, MOLM13, and furthermore was dose-dependent (Figure 4F)