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calcification of the pineal gland starting early in life and an impairment in the noradrenergic innervation to the gland or light detection capacity (ocular mydriases, cataracts) (2, 37)

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It was demonstrated that CSE expression overlaps the absence of CBS, being CSE correlated to increased proliferation and decreased apoptotic rate ( 2 S production, which activates cancer cells proliferation and migration, through ROS/PI3K/AKT/mTOR and MAPK pathways (90)

G.RoglianiP.et al (2016)

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