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14,15 Potential Direct Effects on the Heart Although the systemic indirect effects of GLP-1RAs are well established as the primary drivers of their clinical benefit in HF, emerging preclinical and mechanistic evidence suggests GLP-1RAs may also exert some direct cardioprotective effects, as discussed below

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In addition to serving as a biomarker, the oral microbiota also directly influences local tissue integrity and disease susceptibility

Firstly, am not a doctor, but this view stems from decades of experience in Healthcare delivery and understanding of incentives of various stakeholders

Gut (2017) 66:18090