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Of potential relevance, it has been shown that tricyclic antidepressants like amytriptiline, sensitized against APAP hepatoxicity by inhibiting acidic sphingomyelinase (ASMase), which resulted in lysosomal cholesterol accumulation

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10.1016/j.molimm.2018.12.008 181

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Always consult with your doctor about any medications and supplements you are currently taking so they can best determine if glutathione is safe for you