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308 Experimentally-induced depletion or attenuation of reactive astroglia markedly exacerbates the clinical progression, spread of inflammation and tissue loss in EAE during the induction phases of the disorder, 81,309,310 whereas similarly induced depletion of proliferating reactive astrocytes at later times during the progressive phase ameliorates disease, and this amelioration is at least in part due to removal of astrocyte Ccl2 production

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Gastroparesis and severe gastrointestinal injuries Gastroparesis is the signature injury in GLP-1 litigation

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Once patients stop taking them, the weight loss effects often fade, and potential risks like bone loss, muscle reduction, and persistent nausea have raised concerns about their long-term safety