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2023 Dec 14;389(24):2221-2232
162,163 GLP-1 RAs decrease inflammation through modulation of the function of immune cells and lowering pro-inflammatory cytokines like TNF- and IL-6
In the absence of structural information for the GLP-1R, the design of acid-containing ligands was driven by SAR and the observation that polarity was better tolerated in the benzimidazole (red) region (Fig
Brown, S
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