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Vitamin B12 may reduce the effectiveness of some chemotherapy drugs, such as methotrexate or 5-fluorouracil, and may also be impacted by medications like metformin, proton pump inhibitors (PPIs), and certain antibiotics (e.g., chloramphenicol)

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At 10 nM concentration in intestinal cells, KPV cuts NF-B-driven reporter activity significantly compared to IL-1 stimulation alone