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these factors make GLP-1 RAs an alternative initial treatment option, with or without metformin based on glycemic needs, in T2DM patients with indicators of high-risk or established heart failure (HF) or CKD who cannot tolerate an SGLT2 inhibitor

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Integrative multi-omics approaches may identify responder phenotypes, optimize circadian-aligned dosing, and advance systems-level nutraceutical strategies to restore homeostasis in PCOS

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