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Muscle injury and regeneration: In muscledamage models, TB500 Fragment (1723) activates satellite cells, promotes their proliferation, and supports regeneration of damaged myofibers, likely via Aktmediated signaling and enhanced cell motility

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This concept is reinforced by (1) improvement of sensory and motor behavioral deficits, (2) diminution in histopathological changes in the spinal cord, (3) alleviation in hyperalgesia, (4) reduction of inflammation through inhibition of i-NOS, (5) activation of the PKA/CREB pathway to improve neuroprotection and cell survival, (6) amelioration of inflammation in neurons via increasing the anti-inflammatory markers of M2 microglia phenotype