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In practice, this is unlikely to significantly reduce lisdexamfetamine's efficacy, but patients should be advised to take lisdexamfetamine consistently each morning and report any perceived changes in effectiveness to their prescriber

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Another mouse model involves expressing a human mutant -Gal A in mice with a GLA knockout background, along with overexpressing a Gb3 synthase and serve as a model to study active-site-specific chaperon therapy [33]