Individual medical history, medications, metabolic health, inflammation status, and goals should always be evaluated first
For many people, these options can be effective and more accessible while newer medications like retatrutide are still being studied
Targeted PubMed searches yielded 8 high-quality peer-reviewed references meeting criteria, falling short of the 12-reference threshold
For these presentations, PRP and orthobiologic treatment have demonstrated meaningful clinical outcomes, with many patients returning to full activity without surgical intervention
Third, removal of both the gonads and adrenal glands at birth did not impact on brain estradiol or testosterone concentrations (Konkle and McCarthy, unpublished observations)