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Smoking and regular alcohol intake work the same way, adding oxidative burden your antioxidant system has to absorb

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[5] It is a very important enzyme in protecting the cell from oxidative damage by reactive oxygen species (ROS)

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identified and verified ferroptosis-related genes (ATF3, IL-6, IL-1B and EGR1) in the synovial tissue of OA, which were possibly associated with synovial hyperplasia [135]