Spastic paraplegia, which is exclusive to CPT1C and has nothing in common with CPT1A deficiency, is most likely caused by a dominant genetic variant in CPT1C (Rinaldi et al., 2015)
Memory (escape latency in the Morris water maze test), neurotransmitters (acetylcholine, dopamine, gamma-amino butyric acid (GABA)), and neurochemicals (BDNF, catalase, glutathione, Amyloid Beta and cyclic GMP) were analyzed from whole brain samples in young (8-weeks-old) and aged (16-months-old) rats following 12 days of supplementation (100 mg/d HED of 1-MX [UPLEVEL, Ingenious Ingredients L.P., Lewisville, TX, USA]) via oral gavage
But it does highlight why combining medication with long-term strategies like balanced nutrition, regular exercise, and behavior changes is essential
Bhatt DL, Szarek M, Pitt B, Cannon CP, Leiter LA, McGuire DK, et al
x Richie JP, et al